Opportunity Information: Apply for RFA CK 23 001
The funding opportunity titled "Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases" (Funding Opportunity Number: RFA CK 23 001) is a discretionary federal grant competition issued by the U.S. Department of Health and Human Services through the Centers for Disease Control and Prevention (CDC), using a cooperative agreement as the funding instrument. The central goal of the program is to support clinical and applied research that can translate into real-world improvements in the prevention, detection, and control of fungal diseases, with an explicit focus on reducing illness and deaths globally from both well-known fungi and emerging fungal threats. In practice, this kind of opportunity typically emphasizes projects that move beyond basic laboratory discovery and instead generate evidence that can be implemented in healthcare settings, public health systems, or outbreak response efforts.
Because the award mechanism is a cooperative agreement, recipients should expect substantial CDC involvement during the project period compared with a traditional grant. Cooperative agreements usually mean the CDC will collaborate with the awardee on technical direction, harmonizing methods, refining protocols, coordinating data sharing, or aligning activities with broader public health priorities. Applicants considering this NOFO would generally need to be prepared for active partnership with CDC staff, regular reporting, and potential coordination with CDC networks or surveillance and response efforts relevant to fungal diseases.
The opportunity sits within the Health funding activity category (CFDA/Assistance Listing: 93.084) and was created on February 28, 2023, with an original application closing date of April 28, 2023. Applications were required to be submitted electronically by 11:59 PM Eastern Time on the due date, which is typical for CDC ERA submissions and implies the use of the CDCs electronic grants systems and federal application platforms.
Funding is relatively concentrated: the notice lists an award ceiling of $1,500,000 and anticipates making one award. That structure signals a preference for a single, high-capacity recipient (or a lead organization working with partners through subawards and formal collaborations) that can carry out a substantial, coordinated research agenda. With only one expected award, competition is likely to have been selective, and proposed projects would typically need to show strong feasibility, experienced leadership, access to relevant patient populations or field settings, and a credible plan for generating actionable outcomes.
Eligibility is broad and includes multiple categories of public and private organizations. Eligible applicants include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other Native American tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations both with and without 501(c)(3) status (excluding institutions of higher education in the nonprofit category as specified); for-profit organizations (other than small businesses); small businesses; and additional applicant types as described in the full eligibility text. This wide eligibility reflects the reality that impactful fungal disease research and control efforts may be led by academic centers, public health agencies, healthcare systems, nonprofit research groups, or private entities with specialized diagnostics or implementation capacity.
In terms of what the program is trying to accomplish, the description emphasizes clinical and applied research intended to reduce morbidity and mortality from fungal infections worldwide. "Clinical" implies work tied to patient care, clinical outcomes, diagnostics in healthcare settings, therapeutic strategies, or clinical epidemiology. "Applied" implies research that can be used directly in public health practice, such as optimizing surveillance approaches, evaluating prevention strategies, improving outbreak detection and response, strengthening laboratory and diagnostic capacity, assessing real-world effectiveness of interventions, or identifying practical ways to reduce exposure and transmission in high-risk settings. The mention of both known and emerging pathogens is also important: it indicates interest not only in long-recognized fungal diseases but also in newly emerging or expanding threats, including those influenced by changing healthcare practices, antimicrobial resistance patterns, climate and environmental shifts, and increased numbers of immunocompromised patients.
Overall, this NOFO is best understood as a CDC-led effort to fund one major project (or a coordinated program led by one recipient) that can generate strong, implementable evidence to improve prevention and control of fungal diseases. The cooperative agreement structure, the global framing, and the single large award all point toward a project with clear public health relevance, strong partnerships, and deliverables that can inform guidelines, interventions, or operational strategies that reduce severe outcomes from fungal infections.Apply for RFA CK 23 001
- The Department of Health and Human Services, Centers for Disease Control and Prevention - ERA in the health sector is offering a public funding opportunity titled "Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.084.
- This funding opportunity was created on Feb 28, 2023.
- Applicants must submit their applications by Apr 28, 2023 Electronically submitted applications must be submitted no later than 1159 pm ET on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
What is the title of this funding opportunity?
The funding opportunity is titled "Clinical and Applied Research Strategies for the Prevention and Control of Fungal Diseases."
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is RFA CK 23 001.
Which federal agency is offering this opportunity?
This is a discretionary federal grant competition issued by the U.S. Department of Health and Human Services (HHS) through the Centers for Disease Control and Prevention (CDC).
What type of funding instrument is being used?
The funding instrument is a cooperative agreement, which typically involves substantial CDC involvement in the project during the period of performance.
What does it mean that this is a cooperative agreement?
A cooperative agreement generally means the CDC will be actively involved with the recipient beyond what is common in a traditional grant. Based on the description provided, this can include collaboration on technical direction, harmonizing methods, refining protocols, coordinating data sharing, and aligning activities with broader public health priorities related to fungal diseases. Recipients should also expect regular reporting and potential coordination with CDC networks or surveillance and response efforts.
What is the overall goal of the program?
The central goal is to support clinical and applied research that can translate into real-world improvements in the prevention, detection, and control of fungal diseases, with an explicit focus on reducing illness and deaths globally from both well-known fungi and emerging fungal threats.
What kinds of projects does this opportunity emphasize?
The opportunity emphasizes projects that move beyond basic laboratory discovery and instead generate evidence that can be implemented in healthcare settings, public health systems, or outbreak response efforts relevant to fungal diseases.
What does "clinical research" mean in the context of this NOFO?
In this context, "clinical" implies work tied to patient care and clinical settings, such as research involving clinical outcomes, diagnostics in healthcare settings, therapeutic strategies, or clinical epidemiology related to fungal infections.
What does "applied research" mean in the context of this NOFO?
"Applied" implies research that can be used directly in real-world public health practice. Examples described include optimizing surveillance approaches, evaluating prevention strategies, improving outbreak detection and response, strengthening laboratory and diagnostic capacity, assessing real-world effectiveness of interventions, and identifying practical ways to reduce exposure and transmission in high-risk settings.
Does this opportunity focus only on known fungal diseases?
No. The description explicitly notes interest in both well-known fungi and emerging fungal threats, including threats influenced by changing healthcare practices, antimicrobial resistance patterns, climate and environmental shifts, and increases in immunocompromised patient populations.
Is the program focused on domestic or global impact?
The program is explicitly framed around reducing morbidity and mortality worldwide (globally) from fungal diseases.
What is the Assistance Listing (CFDA) number?
The Assistance Listing (CFDA) number is 93.084.
What is the funding activity category?
The funding activity category is Health.
How much funding is available per award (maximum)?
The notice lists an award ceiling of $1,500,000.
How many awards does CDC expect to make?
The notice anticipates making one award.
What does it imply that only one award is expected?
With one expected award and a relatively large ceiling, the structure suggests a preference for a single, high-capacity recipient (or a lead organization coordinating partners through subawards and formal collaborations) that can run a substantial and coordinated research agenda. It also implies the competition is likely to be selective.
When was this opportunity created?
The opportunity was created on February 28, 2023.
What was the original application closing date?
The original application closing date was April 28, 2023.
When were applications due and how were they submitted?
Applications were required to be submitted electronically by 11:59 PM Eastern Time on the due date. The description indicates use of CDC electronic grants systems and federal application platforms for submission.
Who is eligible to apply?
Eligibility is broad and includes many public and private organization types, including:
- State, county, and city or township governments
- Special district governments
- Independent school districts
- Public and state-controlled institutions of higher education
- Private institutions of higher education
- Federally recognized Native American tribal governments
- Other Native American tribal organizations
- Public housing authorities/Indian housing authorities
- Nonprofit organizations with and without 501(c)(3) status (excluding institutions of higher education in the nonprofit category as specified)
- For-profit organizations (other than small businesses)
- Small businesses
- Additional applicant types as described in the full eligibility text
Are for-profit organizations eligible?
Yes. The eligibility list includes for-profit organizations (other than small businesses) and also separately includes small businesses.
Are institutions of higher education eligible?
Yes. Both public and state-controlled institutions of higher education and private institutions of higher education are listed as eligible applicants.
Are tribal entities eligible to apply?
Yes. Federally recognized Native American tribal governments and other Native American tribal organizations are included in the eligible applicant categories.
What characteristics would a competitive application typically need to demonstrate (based on the description)?
Based on the description of the program structure and the single expected award, competitive proposals would typically be expected to show strong feasibility, experienced leadership, access to relevant patient populations or field settings, and a credible plan for generating actionable outcomes that can be implemented in practice.
Is the program more oriented toward basic lab science or implementation-ready evidence?
It is oriented toward implementation-ready evidence. The description highlights an emphasis on translating research into real-world improvements in prevention, detection, and control, rather than focusing on basic laboratory discovery alone.
What kinds of deliverables or outcomes is this program aiming to produce?
As described, the program aims to generate strong, implementable evidence that can inform real-world actions such as guidelines, interventions, or operational strategies that reduce severe outcomes from fungal infections.
How might partnerships fit into this opportunity?
The notice structure (one expected award) suggests the funded project may be led by one main recipient that coordinates a broader effort through subawards and formal collaborations. The cooperative agreement structure also indicates close collaboration with CDC staff and potential coordination with CDC networks.
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