Opportunity Information: Apply for HRSA 26 101
Supporting Interventions with Technical Assistance (HRSA-26-101) is a Health Resources and Services Administration (HRSA) Ryan White HIV/AIDS Program (RWHAP) Part F Special Projects of National Significance (SPNS) cooperative agreement designed to speed up the real-world adoption of proven and promising HIV care innovations. The opportunity funds one organization to deliver and evaluate tailored, needs-based technical assistance (TA) for RWHAP recipients and providers that are trying to start up, adapt, or replicate existing interventions. The overall goal is to reduce common implementation roadblocks that prevent good models from taking hold in busy clinical and service settings, and to help sites integrate and sustain innovative HIV care approaches that can improve health outcomes and reduce HIV transmission.
A central focus of the project is implementation support that is practical and customized rather than one-size-fits-all. HRSA notes that sites often struggle to launch interventions because they face competing priorities, limited capacity, and uncertainty about how to adapt an intervention to fit their staffing patterns, workflows, organizational structure, or the specific needs of their client populations. The funded recipient is expected to work closely with participating RWHAP sites to understand these local realities and then provide short-term, tailored support and resources that make adoption feasible. In addition to TA, the initiative includes a one-time funding amount intended to cover start-up costs, giving sites a concrete boost to move from planning to action.
The project design calls for the lead awardee to identify and support a representative set of up to 20 RWHAP recipient and/or provider sites that will participate as subrecipients. These sites are to be organized into two phases, which suggests a staged approach where lessons learned from the first group can inform the second, and where the TA model can be refined as the project progresses. Across both phases, the awardee will help sites jump start efforts to adapt or replicate interventions that may be emerging, evidence-informed, or evidence-based, along with other HIV care innovations. The expectation is not only that sites implement changes, but that the project also generates usable knowledge about what implementation strategies work, for whom, and under what conditions.
Because this is a SPNS-supported effort, it is explicitly rooted in implementation science. That means the award is meant to go beyond simply offering training or general guidance. The recipient is expected to systematically adapt, implement, and evaluate the implementation process itself, building on previous and current HRSA HIV/AIDS Bureau (HAB) investments that have developed and disseminated interventions. In practice, this points to activities like assessing site readiness and barriers, tailoring implementation strategies, documenting adaptations, monitoring uptake and fidelity where appropriate, and evaluating how TA and start-up supports influence successful launch and longer-term sustainment.
The funding mechanism is a cooperative agreement, which typically indicates substantial federal involvement in project direction, collaboration, and oversight compared with a standard grant. HRSA anticipates making one award, with an award ceiling of $1,500,000. Eligible applicants are broad and include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; other tribal organizations; and nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where specified). The original application closing date is July 13, 2026, and the opportunity was created on June 11, 2026.
In plain terms, this opportunity is aimed at closing the gap between knowing what works in HIV care and actually putting it into routine practice across the RWHAP system. By combining tailored technical assistance, limited start-up funding for participating sites, and an implementation science evaluation framework, HRSA is seeking to increase the spread and staying power of HIV care models that can strengthen service delivery, improve patient outcomes, and contribute to lower HIV transmission nationwide.Apply for HRSA 26 101
- The Health Resources and Services Administration in the health sector is offering a public funding opportunity titled "Supporting Interventions with Technical Assistance" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.928.
- This funding opportunity was created on 2026-06-11.
- Applicants must submit their applications by 2026-07-13. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $1,500,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education.
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Frequently Asked Questions (FAQs) - Supporting Interventions with Technical Assistance (HRSA-26-101)
What is the Supporting Interventions with Technical Assistance (HRSA-26-101) opportunity?
Supporting Interventions with Technical Assistance (HRSA-26-101) is a Health Resources and Services Administration (HRSA) Ryan White HIV/AIDS Program (RWHAP) Part F Special Projects of National Significance (SPNS) cooperative agreement. Its purpose is to speed up real-world adoption of proven and promising HIV care innovations by funding one organization to deliver and evaluate tailored, needs-based technical assistance (TA) for RWHAP recipients and providers.
What is the main goal of this program?
The overall goal is to reduce common implementation roadblocks that prevent effective HIV care models from being adopted in busy clinical and service settings. The program aims to help participating sites integrate and sustain innovative HIV care approaches that can improve health outcomes and reduce HIV transmission.
How many awards does HRSA expect to make?
HRSA anticipates making one award under this opportunity.
What is the maximum funding amount available?
The award ceiling is $1,500,000.
What type of funding mechanism is used?
This opportunity uses a cooperative agreement mechanism, which typically involves substantial federal involvement in project direction, collaboration, and oversight compared with a standard grant.
Who is eligible to apply?
Eligible applicants include state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized tribal governments; other tribal organizations; and nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education where specified).
What does the funded organization (lead awardee) need to do?
The funded organization is expected to deliver and evaluate tailored, needs-based technical assistance for RWHAP recipients and providers that are trying to start up, adapt, or replicate existing interventions. The lead awardee is also expected to work closely with participating sites to understand local constraints and realities, then provide short-term, customized support and resources to make adoption feasible.
Who will receive technical assistance under this project?
RWHAP recipients and providers that are attempting to start up, adapt, or replicate existing interventions (including emerging, evidence-informed, and evidence-based interventions, along with other HIV care innovations) are the intended recipients of the tailored technical assistance.
How many participating sites are expected, and how are they involved?
The project design calls for the lead awardee to identify and support a representative set of up to 20 RWHAP recipient and/or provider sites. These sites will participate as subrecipients.
How are the participating sites organized within the project?
The sites are to be organized into two phases. This staged approach suggests that lessons learned from the first phase can inform the second phase, and that the technical assistance model can be refined as the project progresses.
What kinds of interventions or innovations are sites expected to work on?
Across both phases, the awardee will support sites that are adapting or replicating interventions that may be emerging, evidence-informed, or evidence-based, as well as other HIV care innovations. The emphasis is on helping sites move from knowing what works to implementing it in routine practice.
What makes the technical assistance "tailored" in this opportunity?
HRSA emphasizes practical, customized implementation support rather than one-size-fits-all assistance. The funded recipient is expected to assess each site’s local realities (such as staffing patterns, workflows, organizational structure, capacity limits, competing priorities, and client population needs) and then tailor short-term support and resources accordingly.
Why does HRSA emphasize implementation challenges and local context?
HRSA notes that sites often struggle to launch interventions due to competing priorities, limited capacity, and uncertainty about how to adapt an intervention to their environment. The project is designed to directly address these common barriers so that effective models can take hold and be sustained.
Is there any funding available to help participating sites with start-up costs?
Yes. In addition to technical assistance, the initiative includes a one-time funding amount intended to cover start-up costs for participating sites, providing support to move from planning to action.
Is this opportunity focused only on training?
No. Because this is a SPNS-supported effort rooted in implementation science, it is meant to go beyond training or general guidance. The recipient is expected to support real-world implementation and also evaluate the implementation process itself.
What does it mean that the project is rooted in implementation science?
Being rooted in implementation science means the project is expected to systematically adapt, implement, and evaluate the implementation process. This includes understanding barriers and readiness, tailoring strategies to local settings, documenting how interventions are adapted, monitoring uptake (and fidelity where appropriate), and evaluating how technical assistance and start-up supports affect successful launch and longer-term sustainment.
What is HRSA looking to learn or produce through this project?
The expectation is that sites will implement changes and that the project will generate usable knowledge about what implementation strategies work, for whom, and under what conditions. This is intended to strengthen the broader ability of the RWHAP system to adopt and sustain effective innovations.
How does this opportunity connect to prior HRSA HIV/AIDS Bureau (HAB) work?
The project is expected to build on previous and current HRSA HIV/AIDS Bureau (HAB) investments that have developed and disseminated interventions. The new work focuses on accelerating adoption, adaptation, replication, and sustainment in real-world settings.
What is the application deadline?
The original application closing date is July 13, 2026.
When was this opportunity created?
The opportunity was created on June 11, 2026.
In plain language, what problem is this grant trying to solve?
This opportunity targets the gap between knowing what works in HIV care and actually putting those approaches into routine practice. By combining tailored technical assistance, a one-time start-up funding boost for sites, and a structured implementation science evaluation framework, HRSA aims to increase the spread and staying power of HIV care innovations across the RWHAP system.
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