Opportunity Information: Apply for PAR 18 263
The National Institutes of Health (NIH) funding opportunity PAR-18-263, titled "Limited Competition: Centers of Biomedical Research Excellence (COBRE) Phase III - Transitional Centers (P30 Clinical Trial Optional)," is a discretionary grant program designed to help established COBRE programs move from NIH-supported development into long-term independence. In practical terms, the FOA is aimed at COBRE centers that have already built meaningful shared research capacity and a functioning research community and now need a structured bridge to become financially and scientifically sustainable without relying on the earlier phase COBRE model. The mechanism used is the P30 Center Core Grant, and the announcement is marked "Clinical Trial Optional," meaning applicants may propose activities that include clinical trials if appropriate, but a clinical trial is not required.
The core purpose of this Phase III "Transitional Centers" FOA is to sustain and stabilize the key infrastructure that COBRE programs created in earlier phases, especially shared core resources that enable biomedical research across a campus or region. Phase III generally emphasizes keeping high-value cores operating, ensuring that they are well-managed, and positioning them to attract continued usage, service revenue, institutional support, and other external funding. Rather than focusing primarily on starting up new infrastructure, the emphasis is on demonstrating maturity: strong governance, effective operations, and a realistic plan for ongoing support so that the scientific gains and research capacity built under COBRE do not fade once earlier COBRE funding ends.
This is a limited competition opportunity, which means it is not open to the full universe of applicants. It is intended for eligible institutions that are already part of the COBRE pipeline and meet the specific eligibility rules laid out in the full FOA. The eligible applicant types listed include public and state-controlled institutions of higher education and private institutions of higher education. At the same time, the FOA explicitly restricts non-U.S. participation: non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply; non-domestic components of U.S. organizations are not eligible; and foreign components, as defined by the NIH Grants Policy Statement, are not allowed. The net effect is that the work and the supported components must remain within allowable U.S.-based institutional structures under NIH policy for this program.
From an administrative and funding snapshot perspective, the opportunity is categorized under Health (CFDA number 93.859) and is administered by NIH. The grant instrument is a standard NIH grant, and the award ceiling is listed as $750,000. The original closing date provided in the source information is 2019-05-28, indicating this particular posting reflects a historical cycle of the program. Even so, the program description captures the broader intent of COBRE Phase III transitional support: protecting the investments made in research cores and center activities, reinforcing a track record of productivity and effective core use, and moving the center toward a stable funding model that can continue beyond COBRE.
Overall, PAR-18-263 is best understood as a sustainability and independence initiative for mature COBRE centers. It supports the transition from building capacity to maintaining and institutionalizing that capacity, with a strong focus on keeping shared biomedical research resources available and productive, strengthening center operations and governance, and ensuring the center can thrive through diversified support after COBRE funding concludes.Apply for PAR 18 263
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Centers of Biomedical Research Excellence (COBRE) Phase III - Transitional Centers (P30 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.859.
- This funding opportunity was created on 2017-11-29.
- Applicants must submit their applications by 2019-05-28. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $750,000.00 in funding.
- Eligible applicants include: Public and State controlled institutions of higher education, Private institutions of higher education.
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|---|
| NINDS Efficacy Clinical Trials (U01) - Clinical Trial Required Apply for PAR 18 422 Funding Number: PAR 18 422 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Exploratory Clinical Trials (U01 - Clinical Trials Required) Apply for PAR 18 420 Funding Number: PAR 18 420 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Feasibility Clinical Trials of Mind and Body Interventions for NCCIH High Priority Research Topics (R34 - Clinical Trials Required) Apply for PAR 18 417 Funding Number: PAR 18 417 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NCCIH Natural Product Phase II Clinical Trial Cooperative Agreement (U01 Clinical Trial Required) Apply for PAR 18 125 Funding Number: PAR 18 125 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Strategies to Increase Delivery of Guideline-Based Care to Populations with Health Disparities (R01 Clinical Trial Optional) Apply for PAR 18 133 Funding Number: PAR 18 133 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Program Project Grant (P01) - Clinical Trial Optional Apply for PAR 18 421 Funding Number: PAR 18 421 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: Renewal of Centers of Biomedical Research Excellence (COBRE)(P20 Clinical Trial Optional) Apply for PAR 18 264 Funding Number: PAR 18 264 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Centers of Excellence for Translational Research (CETR) (U19 Clinical Trial Not Allowed) Apply for RFA AI 17 042 Funding Number: RFA AI 17 042 Agency: National Institutes of Health Category: Health Funding Amount: $5,000,000 |
| Institutional Development Award (IDeA) Program Infrastructure for Clinical and Translational Research (IDeA-CTR)(U54 Clinical Trial Optional) Apply for PAR 18 265 Funding Number: PAR 18 265 Agency: National Institutes of Health Category: Health Funding Amount: $4,000,000 |
| Centers of Biomedical Research Excellence (COBRE) (P20 Clinical Trial Optional) Apply for PAR 18 266 Funding Number: PAR 18 266 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Youth Violence Prevention Interventions that Incorporate Racism/Discrimination Prevention (R01-Clinical Trial Required) Apply for RFA MD 18 005 Funding Number: RFA MD 18 005 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIBIB Research Project Grant (R01 Clinical Trial Required) Apply for PA 18 418 Funding Number: PA 18 418 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIH-CASIS Coordinated Microphysiological Systems Program for Translational Research in Space (UG3/UH3) (Clinical Trials Not Allowed) Apply for RFA TR 18 001 Funding Number: RFA TR 18 001 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Research on Pre-Exposure Prophylaxis (PrEP) to Prevent HIV in Health Disparity Populations (R01-Clinical Trial Not Allowed) Apply for RFA MD 18 003 Funding Number: RFA MD 18 003 Agency: National Institutes of Health Category: Health Funding Amount: $350,000 |
| NHLBI Clinical Trial Pilot Studies (R34 - Clinical Trial Optional) Apply for PAR 18 463 Funding Number: PAR 18 463 Agency: National Institutes of Health Category: Health Funding Amount: $225,000 |
| Cooperative Centers on Human Immunology (U19 Clinical Trial Optional) Apply for RFA AI 17 040 Funding Number: RFA AI 17 040 Agency: National Institutes of Health Category: Health Funding Amount: $2,400,000 |
| Understanding Immunopathogenesis of Tuberculosis in HIV-1 Infected and Exposed Children (R01 Clinical Trial Not Allowed) Apply for RFA AI 17 039 Funding Number: RFA AI 17 039 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Advanced Postdoctoral Career Transition Award to Promote Diversity in Neuroscience Research (K22) - Clinical Trial Not Allowed Apply for PAR 18 469 Funding Number: PAR 18 469 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NINDS Advanced Postdoctoral Career Transition Award to Promote Diversity in Neuroscience Research (K22) - Clinical Trial Required Apply for PAR 18 468 Funding Number: PAR 18 468 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Initiation of a Mental Health Family Navigator Model to Promote Early Access, Engagement and Coordination of Needed Mental Health Services for Children and Adolescents (R01- Clincal Trial Required) Apply for PAR 18 428 Funding Number: PAR 18 428 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
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